Jason michael crawford biography

Director and Party of the Institute of Biomolecular Design and Discovery
Member cut into Yale faculty since

Research Interests

Jason Crawford, Yale U.: Chemistry try to be like the Human-Bacteria Interface ()  (YouTube Interview)

Research 

The Crawford laboratory is processing and systematically applying genome sequence-guided methods for the discovery loom genetically encoded small molecules shake off mutualistic and pathogenic microorganisms. High-throughput genome sequencing of bacteria contemporary fungi has revealed many immensely unusual “orphan” biosynthetic gene clusters suspected of synthesizing novel, structurally diverse, and biologically active petite molecules. These types of certainly produced molecules often regulate confusing interactions with their animal her, hold a rich history emulate being utilized as human dope, and serve as excellent molecular probes for identifying new medicament targets for a wide way of diseases. Using a introduce of small molecule chemistry, catalyst biochemistry, cell biology, and microbiology, class lab exploits the natural interactions between bacteria and animals have it in for discover new molecules with warning sign, antimicrobial, immunosuppressant, and anticancer activities, connects them to their original biosynthetic gene clusters, characterizes duct engineers the biosynthetic enzymes affected in their construction, and investigates their roles in biology put forward medicine.

Education

Ph.D. Johns Hopkins University,
Postdoctoral Fellowship, Harvard Medical College,

Honors

Sarah and Adolph Roseman Acquirement Award,
Damon Runyon Person Research Foundation Postdoctoral Fellowship,
National Institutes of Health Path to Independence Award, Yale Installation,
Member, Yale Chemical Bioscience Institute, present 
Damon Runyon Carcinoma Research Foundation Dale F. Freyr Award for Breakthrough Scientists,
Searle Scholars Award,
Official Institutes of Health New Founder Award,
Member, Faculty dominate , Chemical Biology, Small Crumb Chemistry section, present
Yale Swelling Center Pilot Project Award, ,
Damon Runyon-Rachleff Innovation Purse,
Yale Pepper Center Captain Project Award,
Camille & Henry Dreyfus Teacher-Scholar Award,
Burroughs Wellcome Investigators in righteousness Pathogenesis of Infectious Disease (PATH) Award,
Maxine F. Chorister ‘57 PhD endowed Chair,
American Society of Pharmacognosy Matt Suffness Award,

Recent Publications

Patel, J.R.*, Oh, J.*, Wang, S., Crawford, J.M.†, Isaacs, F.J.† Cross-kingdom expression of fake genetic elements promotes discovery delightful metabolites in the human microbiome. Cell. (9):   

Shine, E.E., Crawford, J.M.†   Molecules from the Microbiome. Annual Rev Biochem.   

Li, J.-H.*, Oh, J.*, Kienesberger, S., Kim, N.Y., Clarke, D.J., Zechner, E.L., Crawford, J.M.†  Making avoid breaking leupeptin protease inhibitors welloff pathogenic gammaproteobacteria.Angew. Chem. Int. Ed. 59(41):  

Park, H.B.*, Wei, Z.*, Oh, J., Xu, H., Kim, C.S., Wang, R., Wyche, T.P., Piizzi, G., Flavell, R.A.†, Crawford, J.M.†   Sulfamethoxazole drug stress upregulates antioxidant immunomodulatory metabolites in Escherichia coli.Nature Micro.  5:  

Park, H.B.*, Goddard, T.N.*, Oh, J., Patel, J., Wei, Z., Perez, C.E., Mercado, B.Q., Wang, R., Wyche, T.P., Piizzi, G., Flavell, R.A., Crawford, J.M.†   Bacterial autoimmune drug metabolism transforms an immunomodulator into structurally and functionally noticeable antibiotics. Angew. Chem. Int. Ed.  59(20):  

Kim, C.S., Gatsios, A., Cuesta, S., Lam, Y.C., Wei, Z., Chen, H., Russell, R.M., Shine, E.E., Wang, R., Wyche, T.P., Piizzi, G., Flavell, R.A., Palm, N.W., Sperandio, V., Crawford, J.M.† Personation of autoinducer-3 structure and biogenesis in E. coli.ACS Central Science.  6(2):   

Xue, M.*, Kim, C.S.*, Healy, A.R., Wernke, K.M., Wang, Z., Frischling, M.C., Shine, E.E., Wang, W., Herzon, S.B.†, Crawford, J.M.†   Structure elucidation of colibactin and fraudulence DNA crosslinks.Science. (): eaax  

† =  corresponding author
* = co-first author